Re-sterilization: Lidocaine Hydrochloride 2% Injection may be re-sterilized by autoclaving at 121°C (250°F) for 20 minutes. Disinfecting agents containing heavy metals, which cause release of respective ions (mercury, zinc, copper, etc.) should not be used for skin or mucous membrane disinfection as they have been related to incidence of swelling and edema. When chemical disinfection of multi-dose vials is desired, either isopropyl alcohol (91%) or ethyl alcohol (70%) is recommended. Many commercially available brands of rubbing alcohol, as well as solutions of ethyl alcohol not USP grade contain denaturants which are injurious to rubber and therefore, should not be used. It is recommended that chemical disinfection be accomplished by wiping the vial thoroughly with cotton or gauze that has been moistened with the recommended alcohol just prior to use.
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